Join Arbele’s Mission

Senior Clinical Research Scientist is required to design and conduct in vitro and in vivo preclinical proof-of-concept studies and clinical research programs for antibody-drug conjugate (ADC). He/she will also be helping the Head of R&D to supervise researchers to lead preclinical / clinical programs.
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Major Responsibilities / Duties Assigned
1. Study design, sample collection and processing, and data analysis of pharmacological and pharmacokinetics studies in mice and toxicology study in monkeys.
2. Liaise with CROs to conduct translational in vivo xenograft studies and toxicology assessment on monkeys.
3. Liaise with CROs for conducting both research and clinical projects.
4. Quality control and functional verification of the newly manufactured ADC.
5. Preparation of materials required for IND application.
6. Assist clinical operation.
7. Coach junior staff in daily experiments.
8. Conduct literature review for novel payload and new oncology target discovery.
9. Ensure scientific excellence, quality and completeness of key platform initiatives.
10. Collaborate in a multidisciplinary research team in an exciting, fast-paced discovery-oriented environment.

Requirements:
1. Master’s degree or above in molecular biology, biochemistry or relevant subjects, with at least 1 year of experience in life sciences research. Relevant clinical trial and operation experience is preferred.
2. Good research record and reporting documentation.
3. Dynamic team player with positive attitude, self-motivated, hardworking and detailed-minded; strong communication and people skills.
4. Excellent command of English, both oral and writing; fluent in Chinese is a plus.
5. Proactive, independent, clear minded, and mature.

Associate Scientist is required to design and conduct in vitro preclinical proof-ofconcept studies for antibody-drug conjugate (ADC).
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Major Responsibilities / Duties Assigned
1. Conduct experiments to study MOA of drug candidates.
2. Establish assays for screening of potential lead molecules.
3. Undertake basic literature review for research advancement.
4. Support senior scientists to manage research laboratory.
5. Present data to team head and senior management in routine research meetings.
6. Maintain a good laboratory environment, inventory, and facilities.
7. Perform any related duties and projects as assigned.

Requirements:
1. Master in Biological Sciences, Biotechnology, or related disciplines, or BSc. with at least 2 years of experiences in cell culture, PBMC isolation, flow cytometry and relevant assays.
2. Experience in assay development in industry setting is preferable.
3. Good command of English, both oral and written.
4. Strong sense of responsibility; be proactive, independent, and mature

Support technical activities in IVD Department with job duties from experimental implementation, data analysis, prototype production and reporting.
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Major Responsibilities / Duties Assigned
1. Conduct bench level experiments within the company IVD product or technology areas and identify problems and discrepancies.
2. Prepare detailed technical procedures, protocols, and reports.
3. Prepare reports and documentation providing the analysis or summarization of experimental results.
4. Work within project timeframes that are established collaboratively by team members.
5. Ability to collaborate, work effectively and contribute within team, department, and crossfunctional teams.

Requirements:
1. Bachelor’s degree/ Diploma in Medical Laboratory Sciences from a recognised university or technical institute;
2. Registered as a Medical Laboratory Technologist under Part II
3. Valid Practising Certificate issued by the Medical Laboratory Technologists Board.
4. Having work experience in histopathology laboratories is preferred.

Job Description
1. Design and conduct MoA studies of company’s lead molecules
2. Establish and perform in vitro assays for lead optimization
3. Conduct literature review for new oncology targets and technology platforms
4. Manage collaborative research projects with universities and research institutes
5. Oversee project activities in CROs
6. Draft grant applications to fund agencies
7. Ensure scientific excellence, quality, and completeness of key platform initiatives in a fast-paced discovery-oriented environment
8. Report to Chief Technology Officer and other senior managements

Requirements
1. PhD in Biomedical Sciences, Molecular Biology, Biotechnology, Immunology or related disciplines
2. Hands-on experiences in molecular cloning, cell culture, flow cytometry, ELISA and other relevant techniques for immunotherapy research
3. Drug R&D experience in biotech/pharmaceutical companies is a plus
4. Demonstrate a track record of research publications
5. Proficiency in both English and Chinese, both oral and written
6. Be proactive, independent, and mature

Job Description
1. Provide comprehensive project oversight, including the development and management of project timelines, research plans, technology roadmaps, budgets, and progress reporting.
2. Coordinate all laboratory activities and provide scientific supervision and mentorship to research staff.
3. Act as the primary liasion between internal team members and external partners, including CROs and clinical consultants. Seek and integrate expert advice into study plans.
4. Deliver expert scientific guidance on:
・Oncology, immunology, and tumor biology to inform project strategy.
・Biomarker identification, selection, and validation.
・Integration and analysis of complex patient data (genomic, transcriptomic, proteomic).
・Clinical trial design optimization with biomarker-driven endpoints.
・Regulatory pathways (FDA, EMA) and ethical compliance for clinical trials and data usage.
・Implementation of innovative technologies and platforms.

Requirements
1. PhD in biochemistry, microbiology, pathology, or a related life sciences field.
2. A minimum of 4-6 years of experience in pharmaceutical R&D, medtech or the IVD industry.
3. A proven track record of scientific publications and an established network with clinical oncologists and pathologists are required.